Volume 16, Issue 1 (March 2024 2024)                   Iranian Journal of Blood and Cancer 2024, 16(1): 53-58 | Back to browse issues page

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Malek M, Khamseh M E, Faranoush P, Hashemi-madani N, Rahimian N, Ghassemi F, et al . Guideline for Diagnosis and Treatment of Osteoporosis in Transfusion-Dependent Thalassemia Patients. Iranian Journal of Blood and Cancer 2024; 16 (1) :53-58
URL: http://ijbc.ir/article-1-1504-en.html
Guideline for Diagnosis and Treatment of Osteoporosis in Transfusion-Dependent Thalassemia Patients
Mojtaba Malek1 , Mohammad E. Khamseh2 , Pooya Faranoush3 , Nahid Hashemi-madani2 , Neda Rahimian2 , Fariba Ghassemi3 , Mohammad Reza Foroughi-Gilvaee3 , Negin Sadighnia3 , Ali Elahinia3 , Mohammad Reza Rezvany3 , Dorsa Fallah Azad3 , Mohammad Faranoush * 4
1- Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS), Tehran, Iran
2- Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS), Tehran, Iran
3- Pediatric Growth and Development Research Center, Institute of Endocrinology Iran University of Medical Sciences Tehran Iran
4- Pediatric Growth and Development Research Center, Institute of Endocrinology Iran University of Medical Sciences Tehran Iran , faranoush47@gmail.com
Abstract:   (485 Views)
The health-related quality of life and management of patients with thalassemia has significantly improved in recent years due to standard treatments and safe blood transfusions with effective chelation therapy to reduce iron overload. Transfusion-dependent thalassemia is associated with numerous skeletal abnormalities, including osteoporosis, which is a significant cause of morbidity in these patients. Osteoporosis is characterized by low bone mass and an increased risk of fractures, particularly in the lumbar spine and in patients with extramedullary hematopoiesis. It remains a significant problem in adult transfusion-dependent thalassemia, particularly in patients under chelation therapy. A fracture history is significantly associated with lower Dual-Energy X-ray Absorptiometry (DEXA) T/Z scores, which decrease with age. Improved management and modern treatments for transfusion-dependent thalassemia patients with osteoporosis should be prioritized to prevent bone fractures and improve quality of life in older age.
Keywords: Osteoporosis, Transfusion, Thalassemia, Bone mineral density, Fracture.
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: Original Article | Subject: Pediatric Hematology & Oncology
Received: 2023/12/23 | Accepted: 2024/03/13 | Published: 2024/03/25
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